其他
发表于 2025-3-30 10:07:09
Katalin Barkovits,Weiqiang Chen,Michael Kohl,Thilo Brachts differences, in vitro/in vivo differences, age-related differences, and normal/disease differences, and these need to be understood in order to guide rational drug discovery and development. To address this issue, we have developed an absolute quantification method of protein expression, called qu
Pelago
发表于 2025-3-30 16:08:20
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HARD
发表于 2025-3-30 18:20:00
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habitat
发表于 2025-3-30 21:31:51
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ADORE
发表于 2025-3-31 02:46:50
Kaiwen Yu,Zhen Wang,Zhiping Wu,Haiyan Tan,Ashutosh Mishra,Junmin Pengracted much attention through the years as it holds a promise that this drug property can be predicted in silico from the chemical drug structure. Various in vivo methodologies have been used to define and quantify drug exposure in the brain, the most commonly used parameter being logBB, which is th
infelicitous
发表于 2025-3-31 09:01:39
Anja Holtz,Nathan Basisty,Birgit Schillingre is now more focus on measuring or estimating target unbound drug concentrations in the brain and evaluating the quantitative aspects of drug transport across the blood–brain barrier (BBB). The techniques for investigation of the rate and extent of BBB transport of new chemical entities (NCEs) are
退潮
发表于 2025-3-31 11:21:21
Thilo Werner,Michael Steidel,H. Christian Eberl,Marcus Bantschefffunction may be parlayed into meaningful disease applications. The development of impactful human therapies is a difficult and lengthy process; nonetheless, many researchers desire to see their work applied to the treatment of human disease. Significant financial reward will follow functional soluti
Musculoskeletal
发表于 2025-3-31 15:09:43
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不自然
发表于 2025-3-31 18:12:04
Anke Trautwein-Schult,Jürgen Bartel,Sandra Maaß,Dörte Bechery and immortalized brain endothelial cells have been described, issues regarding the retention of BBB properties and scalability have hampered their use for certain applications. Differentiation of stem cells to endothelial cells exhibiting BBB properties offers advantages including high barrier, hu
实现
发表于 2025-4-1 00:28:54
e subjects discussed. It Wa& decided to keep the layout very simple in order to keep costs to a minimum and make the monographs available in the shortest possible time, thus overcoming a common problem in medical literature: that of the material being outdated even before publication.978-3-642-73079-5978-3-642-73077-1