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发表于 2025-3-21 19:10:40
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发表于 2025-3-22 00:15:26
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关心
发表于 2025-3-22 01:32:12
Characteristics of a Diagnostic Test,nt years, companion diagnostics have been developed to preselect patients for specific treatments based on their own biology. In this chapter, we review the metrics commonly used to characterize the performance of a diagnostic test. We then discuss what it means when a diagnostic test returns a posi
Infraction
发表于 2025-3-22 07:33:46
The Parallel Between Clinical Trials and Diagnostic Tests,on to diagnose is whether the new drug has a clinically meaningful efficacious effect. This comparison offers us the opportunity to apply properties pertaining to diagnostic tests discussed in Chap. 3 to clinical trials. Building on the results in Chap. 3, we discuss why replication is such a critic
AWL
发表于 2025-3-22 12:25:47
Incorporating Information from Completed Trials in Future Trial Planning,onsider the Bayesian approach to incorporate existing information into future trial planning. Under the Bayesian approach, prior distributions are used to describe the accumulated knowledge about unknown parameters such as those representing treatment effects. The prior distributions are then used t
exigent
发表于 2025-3-22 13:21:53
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的是兄弟
发表于 2025-3-22 20:11:51
Designing Proof-of-Concept Trials with Desired Characteristics,patients, and if the drug appears to have an effect, whether the size of the effect warrants investment in further development. A number of approaches have been proposed to make a decision for a POC study. In this chapter we review five of them. They are, the traditional hypothesis testing approach,
peptic-ulcer
发表于 2025-3-23 00:25:14
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疲劳
发表于 2025-3-23 03:19:26
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objection
发表于 2025-3-23 05:50:05
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