JAZZ 发表于 2025-3-21 16:38:33
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Birbal Singh,Gorakh Mal,Rajkumar Singh Kalra,Francesco Marottane may mediate a complex array of neural signaling pathways in vivo. Dopamine systems are believed to exert functional effects through these second-messenger signaling pathways via modulation of the activity of more rapidly acting ionotropic glutamatergic, GABAergic, and nicotinic cholinergic neuron外来 发表于 2025-3-22 02:36:35
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Birbal Singh,Gorakh Mal,Rajkumar Singh Kalra,Francesco Marottar antagonists that block the NMDA receptor in a competitive or noncompetitive manner induce schizophrenialike symptoms as well when they are given to humans and also to animals (.–.). More support for the GLU hypothesis derived from postmortem studies showing an increase of NMDA receptor density insed-rate 发表于 2025-3-22 11:52:17
Birbal Singh,Gorakh Mal,Rajkumar Singh Kalra,Francesco Marottad SCN, these pieces of evidence suggest that disturbances in the circadian timing system might be part of the core features of PD and not just a “collateral damage”. According to this view, a disturbed clockwork might actively contribute to neurodegeneration and a chronotherapeutic approach to PD mi会犯错误 发表于 2025-3-22 14:40:58
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Birbal Singh,Gorakh Mal,Rajkumar Singh Kalra,Francesco Marottaons to the striatum and cortex further emphasizes the role midbrain dopamine neurons play in the ability to respond appropriately to environmental cues. Subpopulations of dopamine neurons have been associated with different functions such as reward and motivation, cognition and higher cortical proce遗弃 发表于 2025-3-23 00:29:17
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Birbal Singh,Gorakh Mal,Rajkumar Singh Kalra,Francesco Marottants with Parkinson’s disease (PD). Paradoxically, enzymes for dopamine synthesis and dopamine transporter levels are higher in the gut of PD animal models. Patients with PD often have impairment in gastrointestinal function such as gastroparesis or constipation, which usually appears many years befo