Heretical 发表于 2025-3-23 12:03:07
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Prediction of p,, Values for Phenols, Aromatic Carboxylic Acids and Aromatic Amines,Within any class of substituted aromatic acid or base it is usually found that the acidic dissociation constant will vary in much the same way as that of the corresponding derivative in any other class. In most cases, these changes in acid strength, ∆p.., produced by a substituent in a .- or .-position can be predicted by the Hammett equation.我不明白 发表于 2025-3-24 10:14:32
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Examples where Prediction Presents Difficulties,It is important to recognize limitations to the possibility of predictions and to be on the alert for methods by which these inadequacies can be identified. This is often possible if data on appropriate model compounds are available.HARP 发表于 2025-3-24 15:57:03
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Introduction,many of the p.. values which express the strengths of organic acids and bases. This book seeks to provide guidelines to enable such predictions to be made, illustrating the methods used and giving numerous worked examples.