Philanthropist 发表于 2025-3-21 18:29:16

书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders影响因子(影响力)<br>        http://impactfactor.cn/if/?ISSN=BK0741366<br><br>        <br><br>书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders影响因子(影响力)学科排名<br>        http://impactfactor.cn/ifr/?ISSN=BK0741366<br><br>        <br><br>书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders网络公开度<br>        http://impactfactor.cn/at/?ISSN=BK0741366<br><br>        <br><br>书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders网络公开度学科排名<br>        http://impactfactor.cn/atr/?ISSN=BK0741366<br><br>        <br><br>书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders被引频次<br>        http://impactfactor.cn/tc/?ISSN=BK0741366<br><br>        <br><br>书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders被引频次学科排名<br>        http://impactfactor.cn/tcr/?ISSN=BK0741366<br><br>        <br><br>书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders年度引用<br>        http://impactfactor.cn/ii/?ISSN=BK0741366<br><br>        <br><br>书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders年度引用学科排名<br>        http://impactfactor.cn/iir/?ISSN=BK0741366<br><br>        <br><br>书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders读者反馈<br>        http://impactfactor.cn/5y/?ISSN=BK0741366<br><br>        <br><br>书目名称Paroxysmal Nocturnal Hemoglobinuria and Related Disorders读者反馈学科排名<br>        http://impactfactor.cn/5yr/?ISSN=BK0741366<br><br>        <br><br>

restrain 发表于 2025-3-21 23:39:27

A Multistep Model for the Pathogenesis and Evolution of PNHransformation of PNH into myelodysplasia or leukemia are just several aspects of PNH that are poorly understood. Previous models for the development of PNH are somewhat simplistic and do not address each of these important questions. In this report, we suggest a new multistep model for the pathogenesis and evolution of PNH.

公式 发表于 2025-3-22 01:24:20

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听写 发表于 2025-3-22 06:04:12

Proposals for Classification of the Clinical Stages, Grading of Severity and the Molecular Pathogenesis of Paroxysmal Nocturnal Hemoglobinuriad manner plays an important role in the occurrence of a PNH clone, and that a PNH clone increases or decreases relatively or absolutely through competition between proliferation of WT1-expressing cells and clonal selection against WT1-expressing cells.

一再困扰 发表于 2025-3-22 10:22:02

PNH clone acquires both a survival and a growth advantage?clonal expansion. Indeed, we have detected a preferential hematopoiesis by PNH stem cells when transplanted in mice, supporting the intrinsic growth alteration. Thus, we conclude that PNH clone acquires both a growth and a survival advantage.

受辱 发表于 2025-3-22 15:32:12

The Role of Lymphoid Cells in the Pathogenesis of PNH attack, survive and expand. However, the mechanism responsible for the bone marrow failure and the target of the autoaggressive T cells remains still unknown. Here, we review the the most recent findings and possible mechanisms.

通便 发表于 2025-3-22 18:50:24

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CANT 发表于 2025-3-23 00:03:17

Overview of Paroxysmal Nocturnal Hemoglobinuria: Molecular Geneticswith aplastic anemia have clearly recognizable PIG-A mutant clone. These findings suggest that somatic mutation of PIG-A occurs in normal individuals and that clonal expansion requires extra event(s), such as selection by some pathological condition and/or some additional genetic change.

发表于 2025-3-23 02:23:50

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STRIA 发表于 2025-3-23 05:34:28

Clinical Pathology and natural history of PNH; The French Society of Hematology experience.rogens led to an increased risk of death (∼ 5 fold) in patients with . PNH while it lowered the risk of death (∼ 4 fold) in patients with the AA-PNH syndrome, compared to patients treated by androgens in either group.
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查看完整版本: Titlebook: Paroxysmal Nocturnal Hemoglobinuria and Related Disorders; Molecular Aspects of Mitsuhiro Omine (Professor),Taroh Kinoshita (Profe Conferen