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Toxicology of Biguanidese, phenylethylbiguanide (phenformin), was given marketing approval in the United States in 1957. Due to the serious side effects, however, the compound was withdrawn from the market in the United States and the major European countries about 20 years later. Similar problems occurred with .-butylbigu开头 发表于 2025-3-26 00:20:33
Clinical Pharmacology of Biguanides983; . 1992). Repeated reports of phenformin-associated lactic acidosis led to the withdrawal of this biguanide in the United States in 1977 and in most other countries. Buformin shared the same fate, but metformin escaped withdrawal, even if the use became more restricted. At the same time the UnivARY 发表于 2025-3-26 05:35:20
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