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Optimal Control for Problems with a Quadratic Cost Functional on the Therapeutic Agents,trol in the objective is taken as a positive definite quadratic function. The mathematical advantages of such a formulation are obvious: the Hamiltonian . for the optimal control problem becomes strictly convex in the control . and thus has a unique minimizer, albeit only in the state-multiplier spafaculty 发表于 2025-3-22 09:37:09
Optimal Control of Mathematical Models for Antiangiogenic Treatments,herapeutically sensitive cells to heterogeneous structures of cell populations with varying sensitivities or even resistance. From an optimal control point of view, optimal treatment schedules change from bang-bang solutions with upfront dosing (that correspond to classical MTD approaches in medicin漂白 发表于 2025-3-22 15:37:44
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Concluding Remarks,ents. In the administration of cancer treatments, these questions are still far from being answered conclusively. In this text, we have explored what can be said about this topic from an analysis of minimally parameterized models described by ordinary differential equations using an optimal control机构 发表于 2025-3-23 09:04:34
Heinz Schättler,Urszula Ledzewicz it describes the structure and evaluation of the learner model implemented within VIS (the Vygotskian Instructional System). This software explores the way that Vygotsky’s Zone of Proximal Development can be used in the design of learner models. This theoretical foundation requires the system to ad