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vertebrate
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发表于 2025-3-22 07:56:04
DNA, ,-Platinum and Intercalators: Catalytic Activity of the DNA Double Helix,cated within the grooves or between the base pairs of the double helix. They vary greatly in size from one to several nucleotide residues and their intrinsic properties are modulated by the DNA molecule itself through short- and long-range interactions. Short-range interactions are dictated by the n
背信
发表于 2025-3-22 12:08:36
Indirect Effects of DNA Sequence on 434 Repressor-DNA Interactions,ression by binding to DNA at specific sites and activating or repressing transcription. Numerous DNA-binding proteins have now been isolated and their specific binding sites identified (Harrison 1991). From these studies, it is clear that sequence-specific DNA recognition not only involves direct co
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发表于 2025-3-22 15:56:18
, Repressor: DNA Recognition by ,-Strands,sequence-specific DNA recognition have begun to emerge. In particular, structure determinations of protein-DNA complexes, mostly by X-ray crystallography, have yielded a wealth of information (see Steitz 1990; Freemont et al. 1991; Harrison 1991 for reviews). A frequent mode of interaction is the in
混乱生活
发表于 2025-3-22 20:35:27
Mechanism of Action of Restriction Endonuclease ,RV,e and a restriction endonuclease (Bennett and Halford 1989; Wilson and Murray 1991). For .RV, the recognition sequence is GATATC (Kholmina et al. 1980). The .RV modification enzyme methylates the first adenine within this sequence (Nwosu et al. 1988) while, in the presence of Mg. ions, the .RV restr
osculate
发表于 2025-3-22 21:51:25
DNA Bending by Fos and Jun: Structural and Functional Implications,olymorphic. This structural polymorphism includes bending of the helix axis, changes in helical periodicity and variations in the conformation of individual base pairs. Even if we only consider the individual dinucleotides to be structurally nonequivalent, DNA contains eight distinct structural elem
ALIBI
发表于 2025-3-23 02:25:48
Structure of the TFIIIA-DNA Complex,ene system of the African clawed frog . (Wolffe and Brown 1988). In addition, how the 5S-specific transcription factor III A (TFIIIA) interacts with 5S DNA has proven to be a most interesting problem in structural biology. The elucidation of the primary structure of TFIIIA led to the recognition of
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发表于 2025-3-23 05:51:46
Structure and Function of the Glucocorticoid Receptor DNA-Binding Domain,tures of this mechanism are illustrated by the well-characterized example of the glucocorticoid receptor: on binding the hormone, the receptor translocates from the cytoplasm to the nucleus, where it associates with particular sites in the genome and affects transcription rates of target genes. To d