啤酒
发表于 2025-3-25 05:02:07
Presenilins, APP, and Notch: Proteolysis from Womb to Tomb,eptor, a critical signaling event during cell fate decision in embryonic development. Transition-state analogue γ-secretase inhibitors also block the intramembranous cleavage of Notch, and the transmembrane aspartates of presenilins are required for this proteolysis as well. Thus, presenilins appear
expunge
发表于 2025-3-25 08:05:33
Missorting of the Dendritic Cell Adhesion Molecule Telencephalin in Presenilin-Deficient Neurons,phalin is exclusively expressed in neurons of the telencephalic region, where it is abundantly expressed at the somatodendritic plasmamembrane. Functionally, telencephalin is, like notch, involved in neurite outgrowth. Interestingly, telencephalin is also involved in long-term potentiation. We confi
Peak-Bone-Mass
发表于 2025-3-25 13:17:25
,PS1 Interacts With and Facilitates β-Catenin Turnover,retase activity. Thus, presenilins are required for the transmembrane cleavage of both APP and Notch to generate Aβ and the Notch intracellular domain, respectively. This activity has been coined “regulated intramembrane proteolysis” (.) and is discussed in greater depth elsewhere by Rawson in this
碎石
发表于 2025-3-25 18:53:36
,δ-Catenin, Presenilin, and the Synaptic-Adherens Junction Complex,in involves direct contact between the highly conserved juxtamembrane region of the cadherin carboxy terminus and the Arm-repeat of δ-catenin. The interaction with synaptic elements may involve the PDZ binding domain. In developing mouse brain, staining with δ-catenin antibodies is prominent towards
capsule
发表于 2025-3-25 22:02:20
Vascular Smooth Muscle Cells Are the Primary Target of the Events Leading from Notch3 Mutations to des associate to form a heterodimer. In normal human adult tissues, Notch3 expression is essentially restricted to the vasculature, with Notch3 being detected exclusively in the smooth muscle cells. In CADASIL tissues. there is a dramatic and selective accumulation of the Notch3 ectodomain at the me
爱哭
发表于 2025-3-26 00:57:55
macro-economic circumstances in which a business is situated at any particular point in time, is primarily the domain of economists and strategy scholars. Work opportunity might be an area which network theorists would like to investigate, but may also in part be a random factor or a matter of luck.
brother
发表于 2025-3-26 07:39:45
A. Petit,F. Bihel,C. Alves da Costa,O. Pourquié,Y.-H. Suh,J.-L. Kraus,F. Checler macro-economic circumstances in which a business is situated at any particular point in time, is primarily the domain of economists and strategy scholars. Work opportunity might be an area which network theorists would like to investigate, but may also in part be a random factor or a matter of luck.
防水
发表于 2025-3-26 12:17:40
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Postmenopause
发表于 2025-3-26 14:34:13
,A Presenilin Dependent S3-Like γ-Secretase Cleavage of the β-Amyloid Precursor Protein,
多节
发表于 2025-3-26 17:51:01
Notch from Neurodevelopment to Neurodegeneration: Keeping the Fate