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Clinical Assays for Biological Macromoleculesogics. It is, therefore, essential to develop suitable assays for these assessments. However, development of assays for biological macromolecules poses unique challenges. In this chapter, we review the scientific background of clinical assay development and validation, as well as the common statistiVAN 发表于 2025-3-29 03:40:02
Recent Research Projects by the FDA’s Pharmacology and Toxicology Statistics TeamIn this chapter we summarize some of our recent investigations and findings..We have conducted a simulation study (discussed in Sect. 12.2) to evaluate the increase in Type 2 error attributable to the adoption by some non-statistical scientists within the agency of more stringent decision criteria tprediabetes 发表于 2025-3-29 09:29:16
Design and Evaluation of Drug Combination Studiess for drug combination studies, with a focus on in vitro experiments. Two reference models Loewe additivity and Bliss independence are used for synergy evaluation. A new index based on Bliss independence is introduced, comparable to the interaction index based on Loewe Additivity. An example data sejumble 发表于 2025-3-29 14:13:07
Biomarkers differing roles and applications and statistics plays a critical role in their discovery, validation or qualification and how they are applied and utilised. In this chapter we shall discuss what biomarkers are, the types of data that they generate and the impact on the subsequent statistical analysaddict 发表于 2025-3-29 18:38:03
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Max Kuhninduzierte elektrische Moment oder die Polarisierbarkeit des Moleküls bedeutet. Wird das Molekül von dem hochfrequenten Felde einer einfallenden Lichtwelle im Sichtbaren polarisiert, so spricht man von der optischen Polarisierbarkeit α, auch Elektronen-polarisierbarkeit genannt, da nur die Elektroneendoscopy 发表于 2025-3-30 07:25:33
Yang Lu,Katherine Perez-Morera,Rita M. Cantorinduzierte elektrische Moment oder die Polarisierbarkeit des Moleküls bedeutet. Wird das Molekül von dem hochfrequenten Felde einer einfallenden Lichtwelle im Sichtbaren polarisiert, so spricht man von der optischen Polarisierbarkeit α, auch Elektronen-polarisierbarkeit genannt, da nur die Elektrone