PLE 发表于 2025-3-25 07:16:48
Role of Microtubules in the Genesis of MPTP Neurotoxicityise pattern of cytoskeleton reorganisation and its possible role in their formation and in evoking neurodegeneration remains speculative. To elucidate some aspects of this crucial point the neurotoxin MPTP, l-methyl-4-phenyl-l,2,3,6-tetrahydropyridine, may represent a useful tool.insurrection 发表于 2025-3-25 10:45:16
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Endogenous Brain Catechol Thioethers in Dopaminergic Neurodegenerationt manner from 5 to 50 .M. The apoptotic effect of dopamine was greatly enhanced by subcytotoxic concentrations of he mitochondrial inhibitor, .-methyl-4-phenylpyridinium (MPP.). Similarly, subcytotoxic levels of the mercapturate or homocysteine conjugate of dopamine significantly augmented dopaminei持久 发表于 2025-3-26 00:10:13
Potential Roles of Accelerated Dopamine Oxidation, Altered Glutathione Metabolism, 5-S-Cysteinyl-Dop information derived from studies of the dopaminergic neurotoxicity of 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine and methamphetamine, a new pathological mechanism is proposed that might contribute to an understanding of SNpc cell death in PD. This neurotoxic mechanism is suggested to be initiatedcravat 发表于 2025-3-26 07:07:50
Neurotoxic Factors in Parkinson’s Disease and Related Disorders漫步 发表于 2025-3-26 10:29:00
Neurotoxic Factors in Parkinson’s Disease and Related Disorders978-1-4615-1269-1uncertain 发表于 2025-3-26 14:25:12
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