过时
发表于 2025-3-30 11:15:52
Mechanisms of Motor Neuron Death in ALS,) and apparent fragmentation of the Golgi (Gonatas et al. 1992). A landmark discovery in deciphering the mechanism of the disease came from the identification of the mutations in the gene encoding cytoplasmic superoxide dismutase (SOD1) that underlie about 20% of the instances of inherited disease (
Dissonance
发表于 2025-3-30 14:38:35
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Coeval
发表于 2025-3-30 17:29:29
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Largess
发表于 2025-3-30 21:34:54
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Pathogen
发表于 2025-3-31 04:13:51
,Alzheimer’s Disease: Physiological and Pathogenetic Role of the Amyloid Precursor Protein (APP), itrted vesicles..In neurons, metabolism of APP releasing the Aβ peptide was found to occur at all sorting stations, such as at the ER/cisGolgi and TGN/endosomes producing intracellular Aβ peptide as well as at the cell surface leading to secretory Aβ peptide. Regarding the Aβ species generated in the
probate
发表于 2025-3-31 06:37:09
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FLAGR
发表于 2025-3-31 10:27:08
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难解
发表于 2025-3-31 13:59:41
,ApoE Receptors in the Brain: Novel Signaling Pathways with Potential Relevance for Alzheimer’s Dised to the cytoplasmic tail of APP by the adaptor protein FE65. This two-point interaction suggests that LRP may affect the subcellular localization, routing, and possibly processing of APP. Recently, we also described a novel signaling pathway by which two other members of the family, the VLDL recept