断断续续
发表于 2025-3-28 16:11:30
Activation of fungal silent gene clusters: A new avenue to drug discovery,h no actual product has been characterised. In many cases, these clusters remain silent under laboratory conditions. New technologies based on genetic engineering are available to induce silent genes. Heterologous expression of a silent gene cluster under the control of defined promoters can be appl
宠爱
发表于 2025-3-28 18:44:51
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defray
发表于 2025-3-28 23:15:23
Application of natural product-inspired diversity-oriented synthesis to drug discovery,tegies such as diversity-oriented synthesis (DOS) have enabled the synthesis of natural product-like compounds. The combination of these approaches has both improved the desired biological properties of natural products as well as the identification of novel compounds. Diversity concepts and strateg