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Potential Role of Mast Cells in Regulating Corticosteroid Insensitivity in Severe Asthma,ndeed, a number of in vitro studies using various cell types showed that different mediators produced by activated mast cells, including cytokines, have the capacity to interfere with the therapeutic action of corticosteroids. In patients with severe allergic refractory asthma, the anti-IgE monoclon