紧张过度
发表于 2025-3-27 00:31:45
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Implicit
发表于 2025-3-27 03:32:01
Strategies to Modulate the Blood-Brain Barrier for Directed Brain Tumor Targeting,erized tumors, patient prognosis remains dismal. Many factors have contributed to the challenges of developing effective clinical therapies, such as tumor heterogeneity, immune-suppressive microenvironment, and therapy resistance. From the perspective of therapeutics delivery, one of the main obstac
Scintillations
发表于 2025-3-27 06:30:21
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entitle
发表于 2025-3-27 13:31:10
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边缘带来墨水
发表于 2025-3-27 16:11:51
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left-ventricle
发表于 2025-3-27 20:03:37
Strategies to Enhance the Distribution of Therapeutic Nanoparticles in the Brain by Convection Enhaitate widespread therapeutic distribution within brain parenchyma by creating a continuous pressure-driven bulk flow. However, rapid removal of therapeutics from the brain by the physiological clearance mechanism remains a critical challenge to achieving widespread therapeutic delivery by CED. Nanop
thwart
发表于 2025-3-28 00:34:22
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无所不知
发表于 2025-3-28 04:33:04
Neurosurgical Implant-Based Strategy for Brain Cancer Therapy,selective blood-brain barrier. For many years biodegradable polymers were investigated as potential drug delivery systems. However, polymer technology in the drug delivery setting only truly advanced after the polyanhydrides were tested and demonstrated to be safe and effective platforms for control
喷出
发表于 2025-3-28 07:24:06
Liposome-Templated Hydrogel Nanoparticles for Targeted Delivery of CRISPR/Cas9 to Brain Tumors,larly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) has the potential to significantly advance cancer gene therapy. However, clinical translation of CRISPR/Cas9 for brain cancer treatment requires the development of approaches able to simultaneously overcome cellu
Foam-Cells
发表于 2025-3-28 13:27:29
Methods to Separate, Characterize, and Encapsulate Drug Molecules into Exosomes for Targeted Delivelenges posed by BBB. However, drug delivery to the brain is still a hurdle that has yet to be solved. Due to the tight junctions and high selectivity of the BBB, most active and passive strategies deliver an insufficient or insignificant amount of drug across the protective BBB shield. Recently, exo