高兴一回
发表于 2025-3-23 12:33:06
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Audiometry
发表于 2025-3-23 17:19:40
Adjuvants, the Elephant in the Room for RNA Vaccines,rly understood. Although the attractiveness of mRNA as an immunogen has been recognized already more than thirty years ago, it wasn’t until the current COVID-19 crisis that its full potential was shown. From a fringe approach, it has now become a leading technology in vaccine development which will
严峻考验
发表于 2025-3-23 20:35:42
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伟大
发表于 2025-3-24 02:15:30
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GROVE
发表于 2025-3-24 04:40:54
RNA/Polymer-Based Supramolecular Approaches for mRNA Delivery, a therapeutic modality, mRNA still has issues of poor bioavailability, showing rapid enzymatic degradation in physiological environments and inducing uncontrollable inflammatory responses. Chemical modification of mRNA is a prevalent approach to these issues and effectively reduces mRNA immunogenic
易受骗
发表于 2025-3-24 07:02:45
Delivery Vehicles for Self-amplifying RNA,y into the cytosol. This amplification results in high protein expression from a relatively low dose of saRNA (~100-fold lower than mRNA). The rapid, cost-effective, cell-free manufacturing, low dosage requirement, and acceptable safety profile have drawn spotlight on saRNA, which has recently enter
遗传学
发表于 2025-3-24 11:38:35
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HARP
发表于 2025-3-24 14:51:50
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切割
发表于 2025-3-24 21:36:59
Nonsequential Pre-mRNA Splicing: From Basic Understanding to Impacts on Splice-Manipulating Therapies. The development of antisense oligonucleotides (AOs) to harness the splicing process and manipulate it to treat various inherited and acquired diseases has been boosted by its flexibility and customisation capability. As the amount of research in this space increases, certain aspects need to be c
不幸的人
发表于 2025-3-25 01:14:43
gical insights into diseases pathogenesis and therapeutic intervention. Herein, we introduce a quantitative strategy utilizing isobaric stable isotope-labeling techniques combined with two-dimensional liquid chromatography–tandem mass spectrometry (2D-LC–MS/MS) for large-scale, deep quantitative pro