bypass 发表于 2025-3-28 16:31:01
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Neuroprotection by selegiline and other MAO inhibitors,line is considered including the results of two major prospective ongoing clinical trials and recent evidence on the effects of sustained selegiline therapy on postural blood pressures in parkinsonians is discussed.diathermy 发表于 2025-3-28 23:17:53
Monoamine oxidases: from brain maps to physiology and transgenics to pathophysiology,ges of monoamine oxidases A and B in the brain. A transgenic model of oxidative stress is also described. The relevance of these findings for the physiological and pathophysiological roles of monoamine oxidases is briefly discussed.无辜 发表于 2025-3-29 06:01:39
Determination of regions important for Monoamine Oxidase (MAO) A and B substrate and inhibitor seleconstructed six chimeric MAO enzymes by reciprocally exchanging corresponding N-terminal, C-terminal, and internal segments of MAO-A and -B then determined the catalytic properties of these chimeric enzymes. N-terminal chimerics A.B and B.A were made by exchanging amino acid segments 1–45 and 1–36 oExtricate 发表于 2025-3-29 08:24:18
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Are MAO-A deficiency states in the general population and in putative high-risk populations highly iated with marked changes in monoamine metabolism and appear to be associated with variable cognitive deficits and behavioral changes in humans and in transgenic mice. In mice, some of the most marked behavioral changes are ameliorated by pharmacologically-induced reductions in serotonin synthesis d格言 发表于 2025-3-29 22:56:28
Differential trace amine alterations in individuals receiving acetylenic inhibitors of MAO-A (clorgreated for three or more weeks with 10, 30, or 60 mg/ day of the partially-selective inhibitor of MAO-B, selegiline (1-deprenyl). In comparative studies with other, structurally similar acetylenic inhibitors of MAO, pargyline, an MAO-B > MAO-A inhibitor used in doses of 90mg/day for three or more weFRONT 发表于 2025-3-30 03:03:23
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Deprenyl monotherapy improves visuo-motor control in early parkinsonism, course of Parkinson’s disease (PD) are still debated. The present study was therefore undertaken in order to measure quantitatively changes in visuo-motor control (VMC), consequent to deprenyl monotherapy in early PD. Previous work from our laboratory has shown typical VMC deterioration in PD patie