Biomarker 发表于 2025-3-25 06:11:38
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th the exception of antibody-drug conjugates, these nanomedicines are all devoid of targeting ligands and rely solely on their physicochemical properties and the (patho)physiological processes in the body for their biodistribution and targeting capability. At the same time, many preclinical studies垫子 发表于 2025-3-25 16:19:29
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S. G. Krein DNA and RNA fragments requires that these new “drugs” will need to be delivered in a cell-and organelle-specific manner. Although efforts have been made over the last 50 years or so to develop such delivery technology, no effective and above all clinically approved protocol for cell-specific drug dNAVEN 发表于 2025-3-26 02:00:06
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S. G. Kreinaining pharmacological data relevant to the clinical application of such drugs. For such preclinical studies high-performance liquid chromatography (HPLC) or liquid chromatography mass spectrometry (LC-MS) is generally used. However, these methods do not generate data about the drug distribution in挡泥板 发表于 2025-3-26 09:47:53
S. G. Kreine. Tumor penetration of circulating material is most affected for nanocarriers because of their size and lower diffusion. Due to this, the aid of enzymes that degrade the matrix becomes essential when applying nanocarrier based anticancer therapies like oncolytic viruses or nano-formulated drugs lik灯泡 发表于 2025-3-26 13:52:38
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S. G. Kreinch include cytoskeletal organization, membrane traffic, and .A major issue of modern neurobiology is to understand how neurons extend their neurites to form a functional network. While a large amount of information is available on the extracellular mechanisms driving neuritogenesis, the study of the