进步
发表于 2025-3-25 05:11:43
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美丽的写
发表于 2025-3-25 07:47:59
P. Klopotek,U. Brinkmann,P. Oesterlin,W. Mückenheimughput cell viability screening to address the issues encountered in the classical strategy using a single fitness indicator described above. The method combines a biochemical, luminescence-based approach and two fluorescence-based assay types. The biochemical method assesses cellular fitness by qua
homocysteine
发表于 2025-3-25 12:13:40
H.-J. Cirkel,R. Baumgartl,W. Bette,D. Friede,R. Müller Using a quantitative high-throughput screening (qHTS) approach, we are able to screen large chemical libraries to profile potential small molecule modulators of the HIF-1 signaling pathway in a 1536-well format. This chapter describes two orthogonal cell based assays; one utilizing a β-lactamase re
achlorhydria
发表于 2025-3-25 18:07:04
E. Müller-Horsche,D. Basting,U. Brinkmann,P. Oesterlin,W. Mükenheim Using a quantitative high-throughput screening (qHTS) approach, we are able to screen large chemical libraries to profile potential small molecule modulators of the HIF-1 signaling pathway in a 1536-well format. This chapter describes two orthogonal cell based assays; one utilizing a β-lactamase re
obstruct
发表于 2025-3-25 20:01:01
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SOBER
发表于 2025-3-26 00:25:06
Gary K. Klauminzerafish, with its well-documented advantages over many animal models, is now emerging as a true biosensor of chemical activity. Herein, we draw on nearly a decade of experience developing high-throughput toxicology screens in the developmental zebrafish to summarize the best practices in fulfilling th
猜忌
发表于 2025-3-26 06:32:55
P. Chall,D. van Eck,H. v.d. Pas,F. Kuijpersn. is a valuable resource for scientists pursuing chemical toxicology research. This book will aid scientists and researchers in translating new HTS techniques into standardized chemical toxicology assessment tools that can refine, reduce, and replace animal testing. .978-1-0716-2215-5978-1-0716-2213-1Series ISSN 1064-3745 Series E-ISSN 1940-6029
Delude
发表于 2025-3-26 11:38:45
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circumvent
发表于 2025-3-26 16:29:01
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疯狂
发表于 2025-3-26 18:20:38
H. P. Kortzser-friendly format suitable for modeling and other informatics analysis (e.g., gathering PubChem data for hundreds or thousands of chemicals in a modeling friendly format) directly through the PubChem web portal is not feasible. This chapter aims to introduce two approaches to obtain the HTS assay