地牢 发表于 2025-3-26 20:57:50
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B. H. Vickerynto various drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profil标准 发表于 2025-3-27 06:36:40
W. J. Bremner,L. A. Adams,R. A. Steiners drug development processes has been recognized to be extremely important for approp- ate compound selection and optimization. During discovery phases, the identifi- tion of the critical PK/PD/DM issues of new compounds plays an essential role in understanding their pharmacological profiles and str不遵守 发表于 2025-3-27 12:46:06
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Book 1987hases. In the first phase, attention was paid chiefly to the natural sequence hormone; efforts were channeled to explore its diagnostic use; and nearly all the clinical investigations were coordinated by a single pharmaceutical company. The successes in this area were quite limited and the interestInertia 发表于 2025-3-28 01:15:03
Development of LHRH Antagonistss were found to accomplish a reversible “medical gonadectomy” during continued treatment , through a receptor overload-desensitization mechanism , potent LHRH antagonists are still desired because of their immediate and profound suppression of gonadotropin secretion .追踪 发表于 2025-3-28 04:07:40
LHRH Antagonists with Low Histamine Releasing Activitynine residue in position 6 which, with the L-arginine. of the native molecule and with a hydrophobic cluster of residues in the N-terminal part of the molecule, appears to be a potent canbination for the release of histamine from mast cells.被告 发表于 2025-3-28 06:52:05
LHRH and “LHRH-Like” Factors in the Male Reproductive Tract proteins or peptides in testicular tissue and seminal plasma that have “LHRH-like” properties , the biochemical characteristics of most of these molecules, their relationships to the mammalian hypothalamic LHRH decapeptide and to one another, and their physiological significance remain poorly understood.nonplus 发表于 2025-3-28 13:08:31
Placental LHRH-Like Activityvity interacts within a paracrine system involving chorionic gonadotropin, steroid and prostaglandin (PG) releases. The delineation of this paracrine system within the placenta has led us to reassess and broaden our understanding of the control of placental endocrine function.