SYN
发表于 2025-3-23 13:30:07
Larry L. Barton,Gordon V. Johnson,Yvonne M. Bishope transformations may cause toxicity due to the formation of reactive metabolites. Moreover, the inhibition kinetics are complex, and multiple probe substrates should be used when assessing the potential for DDIs. Finally, AO appears to be amenable to computational predictions of both regioselectivi
易达到
发表于 2025-3-23 16:49:36
Dominique Expertoration of extrahepatic metabolism and transport and application of physiologically based pharmacokinetic (PBPK) models with proteomics data are also discussed. The chapter also provides an overview of the advantages of using such dynamic mechanistic models over static models for clearance predictio
马赛克
发表于 2025-3-23 21:38:25
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neologism
发表于 2025-3-24 00:51:16
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conceal
发表于 2025-3-24 06:16:58
Petra Bauer,Rüdiger Helles” provides the prospect for more reliable reaction phenotyping and assessment of DDI potential. Although extrapolation of the in vitro intrinsic clearance of a glucuronidated drug often under-predicts in vivo clearance, careful selection of in vitro experimental conditions and inclusion of extrahe
细胞膜
发表于 2025-3-24 08:39:49
Shigenao Kawai,Shah Alamombinant enzyme systems utilized in drug metabolism, each of these has different components that can influence the free drug concentration. The physicochemical properties of the test compound are also paramount in determining the influential factors in any deviation between true and apparent kinetic
藐视
发表于 2025-3-24 11:38:18
Brenda Parson Hall,Mary Lou Guerinotactions (DDIs) have been observed for AOs. However, the inhibition kinetics are complex, and multiple probe substrates should be used when assessing the potential for DDIs. Finally, AO appears to be amenable to computational predictions of both regioselectivity and rates of reaction, which holds pro
陶醉
发表于 2025-3-24 17:31:32
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instulate
发表于 2025-3-24 22:37:27
Jean-François Briat,Françoise Cellier,Frederic GaymardThe third problern is the manifestation of the cooperative properties of enzymes in the kinetics of enzymatic reactions and the solution of complex kinetic problems. This problern is espe cially pressing in connection with research on allosteric enzymes, which are responsible for feedback in metabolic proces978-1-4899-2836-8978-1-4899-2834-4
carotid-bruit
发表于 2025-3-25 01:26:01
Graziano Zocchi days, whereas immobilized enzymes can be stable for weeks to months and now even years. Over the last decade, there has been substantial research on immobilizing enzymes at electrode surfaces for biofuel cell and sensor applications. The most commonly used techniques are sandwich or wired. Sandwich