宽度 发表于 2025-3-25 04:13:58
Ia Genes, Gene Products, and Determinantsggested that duplicated A., A., E. and E. genes may exist. Each of them would carry some common Ia determinants and some unique Ia determinants identified by monoclonal antibodies. Random association of the polypeptide chains could generate multiple Ia molecules, and numerous combinatorial determina护身符 发表于 2025-3-25 09:36:08
Antibody and T Cell Recognition of Select Ia Determinants Using the I-A Mutant B6.C-,,es between bm12 and B6 mice. This approach not only allows for comparisons between the antibody and T-cell responses to select Ia determinants, but may also give important insights into the recognition of self Ia antigens.misshapen 发表于 2025-3-25 11:54:17
Factor-Mediated Regulation of the Expression of the H-2 Linked Low Molecular Weight Proteins (LMP)oncanavalin A stimulated T cells. This regulation is coordinate with the regulation of the level of both H-2 and Ia antigens in the same cell line, whereas the level of other cell surface molecules is unaffected.Hdl348 发表于 2025-3-25 17:19:06
Book 1983application of sev eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.爱哭 发表于 2025-3-25 22:22:25
http://reply.papertrans.cn/48/4753/475256/475256_25.png铺子 发表于 2025-3-26 02:35:12
Ia Genes, Gene Products, and Determinantsmap within the I-A subregion, while E. maps to the I-E subregion. A. and E. genes code for a 34,000 dalton polypeptide while A. and E. genes code for a 28,000 dalton polypeptide. The noncovalent association of A.A. and E.E. form the I-A and I-E Ia molecules..Recent studies have confirmed the order oexercise 发表于 2025-3-26 06:01:51
Murine T Cell-Specific IA Antigens: Helper T Lymphocytes Express a Unique ,-Encoded Moleculeity complex (H-2) linked immune response (Ir) genes provide a model wherein the molecular basis for immune regulation can be examined (1). Cellular interactions, cell-mediated antiviral immunity, self-nonself discrimination, and immune suppression are H-2I region controlled traits (1).把手 发表于 2025-3-26 10:39:03
http://reply.papertrans.cn/48/4753/475256/475256_28.pngplacebo-effect 发表于 2025-3-26 15:49:31
http://reply.papertrans.cn/48/4753/475256/475256_29.png渐强 发表于 2025-3-26 19:11:55
Induction of Autoreactive T Cells by Stimulation Across the I-J Subregionsoluble T cell derived suppressor mediator (2) has stimulated a great deal of investigative work on this segment of chromosome (reviewed in 3,4). Determinants controlled by the I-J subregion and defined by alloantibody are expressed on 1) T cell subsets (Ly-l+,2.; Ly-l+,2+; Ly-l.,2+) and solubile me