DENT 发表于 2025-3-23 10:43:38
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Rhomboid Intramembrane Serine Proteases,llular role of rhomboid proteins to broad biological processes, including host-cell invasion by malaria parasites, which is the first implication of these enzymes as possible therapeutic targets in human disease策略 发表于 2025-3-23 20:28:46
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uthors recognised as leaders in their fields.Easy to read de.In recent years a growing number of proteases have been identified that catalyse peptide bond hydrolysis in the plane of the cellular membrane. These so-called ‘intramembrane-cleaving proteases’ (I-CLiPs) are involved in a diverse range of符合国情 发表于 2025-3-24 04:12:17
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The Site-2 Protease at Ten,in a membrane-spanning helix. S2P was the first intramembrane-cleaving protease to be recognized but more has been learned about other such proteins. Fundamental questions about the role and function of S2P remain unanswered. S2P plays a crucial role in mammalian lipid metabolism and the unfolded prpainkillers 发表于 2025-3-24 13:15:57
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GXGD-Type Intramembrane Proteases,, which share their respective active site motifs with their classical counterparts, the aspartate protease I-CLiPs acquired a novel characteristic GxGD active site motif during evolution. These so-called GxGD-type proteases include the presenilin (PS), signal peptide peptidase (SPP), SPP-like prote热烈的欢迎 发表于 2025-3-24 19:04:01
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Proteases of the Rhomboid Family in the Yeast Saccharomyces Cerevisiae,a wide range of cellular functions and developmental processes by intramembrane proteolysis. In yeast, two members of the rhomboid family are known, Rbd2 and Pcp1. Rbd2 is associated with the Golgi apparatus, but its function and its substrates are still unknown. The rhomboid protease Pcp1, located