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Recognizing and Treating Comorbidities of IPF, these, this chapter will highlight the prevalence, clinical approach, and management of the following: acute exacerbation (AE), combined pulmonary fibrosis and emphysema (CPFE), pulmonary hypertension (PH), gastroesophageal reflux disease (GERD), thromboembolic disease, cardiovascular disease, lung cancer, and end-of-life care.