生意行为
发表于 2025-3-26 23:39:36
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COM
发表于 2025-3-27 03:02:46
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ORBIT
发表于 2025-3-27 05:19:45
Integration of Pharmacokinetics, Pharmacodynamics, and Toxicokinetics in Rational Drug Development
对待
发表于 2025-3-27 10:03:55
Avraham Yacobi (Director),Jerome P. Skelly (Deputy
使长胖
发表于 2025-3-27 13:54:49
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Consequence
发表于 2025-3-27 20:29:23
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北京人起源
发表于 2025-3-28 01:50:12
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Engaging
发表于 2025-3-28 03:15:35
Use of Pharmacokinetics and Pharmacodynamics in Preclinical Studies to Guide Dosage Escalation Schem–24 months. Overall, there is now a substantial collection of data which demonstrates that coordination with preclinical pharmacology and toxicology studies can save both time and resources in early clinical trials without a loss of safety.
Afflict
发表于 2025-3-28 06:35:19
Use of Toxicokinetic Principles in Drug Development: Bridging Preclinical and Clinical Studiesationship between safe dosages, pharmacologic-toxicologic activities, and blood levels can guide in selecting early dosages for initial administration to man and in subsequent dosing escalation strategy.
门闩
发表于 2025-3-28 13:06:31
Preclinical Pharmacodynamics of Anxiolytics: Effects of Chronic Benzodiazepine Administrationbserved during chronic administration, suggesting the presence of a “withdrawal” syndrome. Administration of carbamazepine after lorazepam discontinuation attenuated the behavioral and neurochemical withdrawal effects. Studies to determine the cellular mechanisms of these receptor alterations indica