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Tolerance, Historical Reviewchemia, experienced for a duration less than required for injury, occurs prior to a potentially harmful duration of ischemia which the target organ is now “tolerant” to. Although ischemic tolerance is generally assumed to have been discovered in the heart, the story of tolerance dates back to at lea
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Anoxia Resistance in Lower and Higher Vertebrates In contrast, the crucian carp (.) and some North American freshwater turtles of the genera . and . can survive anoxia for hours to months depending upon the temperature. These anoxia-tolerant vertebrates defend their brain ATP (adenosine triphosphate) levels by matching ATP consumption to glycolyti