水汽 发表于 2025-3-23 10:11:43
http://reply.papertrans.cn/47/4665/466473/466473_11.pngostensible 发表于 2025-3-23 17:40:59
http://reply.papertrans.cn/47/4665/466473/466473_12.pngemission 发表于 2025-3-23 20:11:54
The Pathophysiological Basis of Parkinson’s Diseaseof the central nervous system (CNS), and is basically characterized by dysfunction of the dopaminergic nigro-striatal system. It may, or in rare cases it may not, be associated with distinct anatomical damage to melanin-containing neurons of the substantia nigra (SN), changes in the neuronal cytoske特别容易碎 发表于 2025-3-23 23:08:20
Parkinson’s Disease and Its Existing Therapyntal disturbances and disorders of the autonomic nervous system. The degree and combination of the symptoms vary from case to case and during the course of the disease. With consideration of the motor signs of the disease, an akinetic-rigid and a tremor-dominant progress type is differentiated. EquaSOW 发表于 2025-3-24 05:58:56
Medicinal Chemistry of Present and Future MAO-B Inhibitorsients still suffered from tuberculosis. Then, several groups of chemists synthesized molecules with different chemical structures in attempts to create an efficient treatment for this illness. One of these compounds, isonicotinyl hydrazide (isoniazid) was originally synthesized as a necessary intermcraven 发表于 2025-3-24 08:55:23
-Deprenyl: A Unique MAO-B Inhibitors to catalyze the oxidative deamination of biogenic amines to the corresponding aldehyde . It is generally accepted that it exists in two functional isoenzyme forms, MAO-A and MAO-B, each of which shows preferential affinity for substrates and specificity towards inhibitors . Available evid最初 发表于 2025-3-24 10:40:21
http://reply.papertrans.cn/47/4665/466473/466473_17.pngtransdermal 发表于 2025-3-24 16:03:56
http://reply.papertrans.cn/47/4665/466473/466473_18.pngAnterior 发表于 2025-3-24 21:48:04
http://reply.papertrans.cn/47/4665/466473/466473_19.pngMets552 发表于 2025-3-25 01:19:18
Pharmacokinetics and Clinical Pharmacology of Selegilineetabolized via MAO-B . By inhibiting this enzyme the dopamine concentration in the brain is increased . Selegiline has also been shown to inhibit the uptake of dopamine and noradrenaline . Due to these properties, selegiline is widely used in the treatment of Parkinson’s disease (PD) as eit