保守党
发表于 2025-3-23 10:43:36
Insulin and Insulin-Like Growth Factor-1 Receptors and Signaling Pathways: Similarities and Differen, these hormones/growth factors also share many similarities. The hormones have similar tertiary structures, and they share ~50% amino acid identity. Both insulin and IGFs interact with specific cell surface receptors that represent one sub-class of the tyrosine kinase receptor family. The signaling
Myofibrils
发表于 2025-3-23 16:14:58
The JAK-STAT Pathwaytivation. Together with NF-kB, NF-AT, and SMADs, STATs represent one of four types of transcription factors that are rapidly translocated from cytosol to nucleus in a fashion that is dependent on phosphorylation/dephosphorylation events. This short chapter cannot comprehensively review all that is k
SOB
发表于 2025-3-23 20:57:15
Erythropoietin, Thrombopoietin and Leptin Receptors substrates including the receptor itself, leading to the activation of distinct signaling pathways. This review will focus first on the structure and biological properties of Epo, Tpo, leptin and their receptors. The second part will summarize the signal transduction pathways induced by these three
使闭塞
发表于 2025-3-24 01:39:26
Signal Transduction and Structure of Nuclear Receptorsn with a large variety of hormonal and other regulatory, as well as metabolic signals, ii) integrate diverse signaling pathways as they correspond themselves to targets of post-translational modifications, and iii) regulate the activities of other signaling cascades (commonly referred to as “signal
Irremediable
发表于 2025-3-24 05:17:26
Estrogen Receptor Betare is an equal and opposite reaction, understanding knock out phenotypes would be easy. Unfortunately, in endocrinology, it is impossible to make a single alteration without eliciting a cascade of responses.
Bronchial-Tubes
发表于 2025-3-24 10:31:18
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健谈
发表于 2025-3-24 14:42:57
The EGF Receptor Signaling Systemive extracellular signals. Implicated in organ morphogenesis, maintenance and repair, upregulated EGFR signaling also correlates with a wide variety of tumors, especially at progression to invasion and metastasis. Thus, EGFR and its resultant signals are therapeutic targets in cancer and wound healing treatments.
Meditative
发表于 2025-3-24 16:28:49
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Sedative
发表于 2025-3-24 20:13:58
G Proteins and G Protein-Coupled Receptorsory checkpoints and possible targets for therapeutic intervention. Cell surface receptors include G protein-coupled receptors (GPCRs), as well as, ion channels and enzyme-linked receptors. GPCRs are responsible for physiological responses as diverse as visual perception, neurotransmission, cell growth and cell differentiation.
果仁
发表于 2025-3-24 23:09:08
Endothelin G Protein-Coupled Receptorsic neural-crest lineage and of the central and peripheral nervous systems. The ability of all these tissues to synthesize ETs and the fact that the blood concentrations of ET. are below those able to evoke sizeable biological effects led to the contention that these peptides almost exclusively act through autocrine-paracrine mechanisms.