蒸发 发表于 2025-3-26 22:39:13
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1064-3745 ology. serves as a valuable reference resource for translating new HTS techniques into standardized chemical toxicity assessment tools in order to advance modern toxicology research to a new era where HTS techniques can partially replace the prevailing animal models..978-1-4939-8171-7978-1-4939-6346-1Series ISSN 1064-3745 Series E-ISSN 1940-6029Dorsal-Kyphosis 发表于 2025-3-27 07:39:53
Srilatha Sakamuru,Matias S. Attene-Ramos,Menghang Xiamisshapen 发表于 2025-3-27 13:13:59
Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Si Using a quantitative high-throughput screening (qHTS) approach, we are able to screen large chemical libraries to profile potential small molecule modulators of the HIF-1 signaling pathway in a 1536-well format. This chapter describes two orthogonal cell based assays; one utilizing a β-lactamase re现晕光 发表于 2025-3-27 16:40:04
http://reply.papertrans.cn/43/4269/426806/426806_35.pngexophthalmos 发表于 2025-3-27 18:48:15
Better, Faster, Cheaper: Getting the Most Out of High-Throughput Screening with Zebrafishafish, with its well-documented advantages over many animal models, is now emerging as a true biosensor of chemical activity. Herein, we draw on nearly a decade of experience developing high-throughput toxicology screens in the developmental zebrafish to summarize the best practices in fulfilling th返老还童 发表于 2025-3-28 00:24:15
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Using β-Lactamase and NanoLuc Luciferase Reporter Gene Assays to Identify Inhibitors of the HIF-1 Sies or those with inadequate oxygen concentrations, activation of the HIF-1 transcription factor allows for subsequent activation of target gene expression implicated in cell survival. As a result, cells proliferate through formation of new blood vessels and expansion of vascular systems, providing n爱得痛了 发表于 2025-3-28 13:07:02
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