投票 发表于 2025-3-28 18:16:53
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High-Throughput Cell Toxicity Assays, strategy to find hit and lead compounds for drug discovery projects in the pharmaceutical industry [.], an understanding of the cell toxicity profile of hit molecules from HTS activities is fundamentally important. Recently, there has been a resurgence of interest in phenotypic drug discovery and t上流社会 发表于 2025-3-29 10:14:34
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Application of Imaging-Based Assays in Microplate Formats for High-Content Screening,ly not measurable by any other method. Collectively referred to as high-content screening (HCS), or high-content analysis (HCA), these methods rely on an expanding array of imaging hardware and software automation. Coupled with an ever-growing amount of diverse chemical matter and functional genomic冷淡周边 发表于 2025-3-29 16:42:49
Application of Fluorescence Polarization in HTS Assays,r interactions. This chapter reviews the basic theory of fluorescence polarization, the underlying principle for using fluorescence polarization to study interactions between small-molecule fluorophores and macromolecular targets, and representative applications of fluorescence polarization in high-throughput screening.Commission 发表于 2025-3-29 23:39:51
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https://doi.org/10.1007/978-1-4939-3673-1high throughput screening assays; complex cellular systems; mass spectrometer techniques; drug discover印第安人 发表于 2025-3-30 06:35:48
Protein Kinase Selectivity Profiling Using Microfluid Mobility Shift Assays,Biochemical selectivity profiling is an integral part of early drug development. Typically compounds from optimization phase are regularly tested for off-target activities within or across target families. This article presents workflow and critical aspects of biochemical protein kinase profiling based on microfluidic mobility shift assays.