自爱
发表于 2025-3-25 03:34:09
Targeting Hsp90 Function to Treat Cancer: Much More to Be Learned,ver, Hsp90 is unique because it is not required for the biogenesis of most polypeptides. Instead, it oversees a surprisingly diverse network of conformationally labile client substrates that regulate signaling pathways and gene expression. Many of the processes modulated by Hsp90 are dysregulated in
HAIL
发表于 2025-3-25 07:41:59
http://reply.papertrans.cn/43/4251/425012/425012_22.png
concentrate
发表于 2025-3-25 11:52:10
http://reply.papertrans.cn/43/4251/425012/425012_23.png
myocardium
发表于 2025-3-25 16:52:06
Cdc37 and protein kinase folding,in protein kinase folding is dependent on direct interaction between the chaperone and the N-lobe of the kinase catalytic domain. In addition, Cdc37 can inhibit the ATPase activity of Hsp90 that is thought to promote assembly of the kinase client with both chaperone proteins. Treatment of cells with
CLOUT
发表于 2025-3-25 22:23:25
http://reply.papertrans.cn/43/4251/425012/425012_25.png
canvass
发表于 2025-3-26 00:31:44
y. Moreover, target validation studies indicate BACE1 to be a high priority anti-amyloid therapeutic target for the treatment of AD. However, inhibition of BACE1 activity may not be completely free of mechanism-based consequences related to possible roles of BACE1-dependent APP/AICD signaling in cog
高度表
发表于 2025-3-26 05:52:41
William B. Pratt,Yoshihiro Morishima,Yoichi Osawa) and one late-onset risk-factor (.), strong evidence exists suggesting the presence of additional AD genes for both forms of the disease. The hunt for these genes is aggravated by several factors that generally complicate the identification of complex disease genes: locus and/or allelic heterogenei
majestic
发表于 2025-3-26 09:26:49
Daniel R. Ciocca,Mariel A. Fanelli,F. Dario Cuello-Carrión,Stuart K. Calderwoodears. Exact register parallelism is emerging as a common structural motif for amyloid fibrils and may also represent a key organizing principle for amyloid oligomers. Also, characterization of the interactions of A. with transition metals has opened up a new vista of potential pathogenic interaction
VAN
发表于 2025-3-26 13:23:15
http://reply.papertrans.cn/43/4251/425012/425012_29.png
提名
发表于 2025-3-26 16:48:43
Andre-Patrick Arrigo) and one late-onset risk-factor (.), strong evidence exists suggesting the presence of additional AD genes for both forms of the disease. The hunt for these genes is aggravated by several factors that generally complicate the identification of complex disease genes: locus and/or allelic heterogenei