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The Emerging Role of Epigenetics,difications, and RNA-associated editing, lead to the heritable silencing/activation of genes without changes in DNA sequence. The critical role of epigenetic modifications has been demonstrated in normal and disease development in humans. With the advent of next-generation sequencing, the technologi值得赞赏 发表于 2025-3-22 06:14:45
Mitochondria Genome Mutations and Cardiovascular Diseases,uding environmental, lifestyle, and genetic factors. Mitochondria (mt) are indispensable organelles harboring a 16,569 base-pair, circular DNA genome that encodes 13 proteins involved in electron transport and oxidative phosphorylation system (OXPHOS). Critical components of OXPHOS are encoded by thPalate 发表于 2025-3-22 10:10:57
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Progress of Genomics in Atherosclerosis-Coronary Heart Disease and Myocardial Infarction,lity. Albeit a complete picture of its biological nature hasn’t been clarified yet, it is acknowledged that CAD, as one of common complex disorders, results from a combination of heritable and environmental factors. In the past decades, the advent and rapid growth of genome-wide association studiesCholesterol 发表于 2025-3-23 02:11:33
Progress of Genomics in Cardiac Conduction and Rhythm Disorders,ibution of epigenetics to heart rhythm disorders has also recently been highlighted in common pathologies. This chapter provides an overview to recent progress of genomics in cardiac conduction and rhythm disorders, including long QT syndrome (LQTS), Brugada syndrome (BrS), short QT syndrome (SQT),NAUT 发表于 2025-3-23 05:36:05
Progress of Epigenetic Changes in Heart Failure,maintain its function are composed of transcriptional control and signaling systems. Epigenetic processes play vital roles in the process. These include DNA and histone modification and classes of regulatory RNAs, such as microRNAs and long noncoding RNAs. Here, we review this emerging landscape to