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Book 2020proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many o改进 发表于 2025-3-22 12:02:21
https://doi.org/10.1007/978-1-349-13445-8the various members of this network. In this chapter we describe the emerging working principles of the Hsp70 machine and its co-chaperones, and highlight how mechanistic aspects of this network are tied to distinct protein folding functions.lambaste 发表于 2025-3-22 15:09:19
https://doi.org/10.1007/978-3-031-05017-6 from Hsf1, releasing Hsf1 to induce the full arsenal of cellular chaperones to restore protein homeostasis. In metazoans, this cell-autonomous feedback loop is modulated by the microenvironment and neuronal cues to enable tissue-level and organism-wide coordination.名字 发表于 2025-3-22 21:01:07
https://doi.org/10.1057/9780230273979ancer-cell-autonomous activity of chaperones in human patients and mouse models of cancer, discuss the mechanisms by which this non-cell-autonomous activity is mediated and provide an evolutionary perspective on the basis of this phenomenon.eulogize 发表于 2025-3-22 21:23:33
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