defray
发表于 2025-3-23 13:38:28
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散开
发表于 2025-3-23 15:24:14
Adaptive Designs with Survival Data method, the Fisher’s combination test approach, and some extensions of the conditional error rate principle. In this chapter we focus on the combination testing approach and briefly describe some problems that might arise in adaptive survival trials.
Trigger-Point
发表于 2025-3-23 18:15:35
Multiple Testing in Adaptive Designsirst describe the various sources of multiplicity which can arise in such trial designs. To avoid an inflation of the overall Type I error rate beyond a pre-specified significance level ., such considerations have to be taken into account. In Sect. . we review the closure principle, which is a power
成份
发表于 2025-3-23 23:34:12
Applications and Case Studieswith multiple treatment arms where, based on interim results, one or more arms are selected. The second is the design where one or more pre-specified subsets of a population are selected for further investigation, the latter designs are called .. The combination testing principle together with the c
Demonstrate
发表于 2025-3-24 04:53:38
Perspektiven der Arrhythmiebehandlungt with a brief historical survey of group sequential tests. The notation and the construction of statistical tests that are based on the repeated significance testing approach are described in the following section. We then address the basic issues—power and average sample size—for the assessment of
AROMA
发表于 2025-3-24 07:11:10
Nike Plaßmeier,Gerald A. Strakaocedures that were originally developed in the literature (which we refer to as classical group sequential designs) make this assumption. In practice, the situation with equally sized stages often occurs. Namely, in all cases when there is no specific reason for assuming different stage sizes the sa
季雨
发表于 2025-3-24 13:27:56
https://doi.org/10.1007/978-3-531-90637-9f using the decision boundaries designed for equally sized stages to the more general case of unequally sized stages. We also briefly describe a worst case scenario adjustment procedure. We then sketch the use of designs with prefixed sample sizes that need not to be equal to each other. A more gene
加花粗鄙人
发表于 2025-3-24 15:22:32
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BUMP
发表于 2025-3-24 19:25:47
https://doi.org/10.1007/978-3-322-85101-7clinical trials. These are one- and two-sample tests for normally distributed observations where the variance .. is unknown, one- and two-sample tests for binary data, and statistical inference on time-to-event (survival) data. For survival data analysis, we will slightly modify the notation in orde
CULP
发表于 2025-3-25 00:55:39
Norbert Rippberger,Heinz Karrascheffect and corresponding sample sizes may be reassessed at an interim analysis from unblinded interim data. In this case designs are required that guarantee Type I error rate control. Bauer (Biometrie und Informatik in Medizin und Biologie 20:130–148, 1989) and Bauer and Köhne (Biometrics 50:1029–10