Fibrillation
发表于 2025-3-30 11:06:08
G Protein-Coupled Receptor Kinases (GRKs) History: Evolution and DiscoveryPCR field. The existence of GRKs and arrestins revealed the primary mechanism for termination of GPCR signaling. GRKs appeared in evolution long before animals, and it remains to be elucidated whether their first substrates were GPCRs or other proteins. It is also unclear whether and how GRKs are ac
Deduct
发表于 2025-3-30 14:59:59
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botany
发表于 2025-3-30 17:52:58
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Dysplasia
发表于 2025-3-30 21:57:58
Molecular Basis for Targeting, Inhibition, and Receptor Phosphorylation in the G Protein-Coupled Recignals during stress. The seven human GRKs belong to three subfamilies with distinct structural features and membrane targeting mechanisms. Although crystal structures representing each subfamily have now been reported, a recent series of GRK4 subfamily structures provide new information about how t
MANIA
发表于 2025-3-31 02:58:19
“Barcode” and Differential Effects of GPCR Phosphorylation by Different GRKster of modern medicine. Multiple site phosphorylation of GPCRs by G protein-coupled receptor kinases (GRKs) plays an essential role in the regulation of various functions and signaling cascades of a receptor. Research in recent years has elucidated a common mechanism by which different ligand-bound
得意人
发表于 2025-3-31 07:58:44
Cell-Type Specific GRK2 Interactomes: Pathophysiological Implicationsreceptors, GRK2 can phosphorylate and/or functionally interact with a complex network of cellular proteins in a cell-type and physiological context-dependent way. A combination of such canonical and noncanonical interactions underlies the participation of this kinase in the control of cell migration