Submitted on: 12 November 2016.
Revised on: 12 December 2016.
Accepted on: 03 February 2017.
___________________BIOINFORMATICS---OXFORD UNIV PRESS
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Submitted on: 01 December 2002.
Revised on: 08 March 2003.
Accepted on: 04 May 2003.
___________________BIOINFORMATICS---OXFORD UNIV PRESS
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