Senescent 发表于 2025-3-23 13:12:22
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J. Nagarjun,S. Manimaran,M. KrishnaprakashDuchenne muscular dystrophy (DMD). Systemic administration of antisense phosphorodiamidate morpholino oligomers (PMOs) targeting exons 6 and 8 in dystrophin mRNA of the canine X-linked muscular dystrophy model in Japan (CXMD.) that lacks exon 7, restored dystrophin expression throughout skeletal mustravail 发表于 2025-3-23 20:19:48
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https://doi.org/10.1007/978-3-540-88087-5for myofiber integrity. Exon skipping therapy is an emerging strategy for restoring the open reading frame of the . gene to produce functional protein in DMD patients by skipping single or multiple exons. Although antisense oligonucleotides are able to target pre-mRNA for exon skipping, their half-lhedonic 发表于 2025-3-24 07:26:54
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Fuzziness in Information Systemsinvolves the following two aspects: (1) efficiency and accuracy of exon skipping and levels of dystrophin expression determined by RT-PCR, immunochemistry, and western blotting; (2) therapeutic effects on muscle pathology and functions assessed by histology and functional assays including grip strenTracheotomy 发表于 2025-3-24 18:13:28
Studies in Systems, Decision and Control protein. Antisense oligonucleotide (AON)-mediated exon skipping has been developed as a method to restore the reading frame, which allows the synthesis of internally truncated, but partially functional dystrophin proteins, as found in the less severe Becker muscular dystrophy (BMD). This approach i先兆 发表于 2025-3-24 20:09:05
Toshifumi Yokota,Rika MaruyamaIncludes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts严重伤害 发表于 2025-3-25 00:21:56
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