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Fundamentals of Enzyme Kineticsto understanding enzyme kinetics is having a clear grasp of the meanings of “enzyme” and “catalysis.” Catalysts are reagents that can increase the rate of a chemical reaction without being consumed in the reaction. Enzymes are proteins that form a subset of catalysts. These concepts are further expl腐烂 发表于 2025-3-31 07:12:49
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Reversible Mechanisms of Enzyme Inhibition and Resulting Clinical Significance major cause of clinically significant drug–drug interactions. This chapter defines the four reversible mechanisms of inhibition exhibited by drugs: competitive, noncompetitive, uncompetitive, and mixed competitive/noncompetitive. An in vitro procedure to determine the potential of a drug to be a reCoronary-Spasm 发表于 2025-3-31 14:37:54
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Consideration of the Unbound Drug Concentration in Enzyme Kineticse. In all but the very simplest in vitro system, these drug concentrations can be influenced by a variety of nonspecific binding reservoirs that can reduce the available concentration to the enzyme system under investigation. As a consequence, the apparent kinetic parameters that are derived, such aSTYX 发表于 2025-3-31 23:27:45
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