睨视
发表于 2025-3-27 01:03:00
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maladorit
发表于 2025-3-27 04:59:14
,Harnessing “the Cloud” on Your Tablet,roteins. As such, MA has enabled a vast exploration of sequence-specific methods and reagents, ushering in the modern era of zinc finger-based applications that are described in this volume. The first zinc finger nuclease to cleave an endogenous site was created using MA, as was the first artificial
Chivalrous
发表于 2025-3-27 07:32:12
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附录
发表于 2025-3-27 11:56:31
Controlling Your Mac: Launchpad,ement of gene expression as well as targeting specific sites on DNA for methylation, recombination, and cleavage. To effectively and quickly conduct selections that consider the synergistic mode of DNA binding by zinc fingers, Isalan and Choo in Aaron Klug’s lab devised a bipartite phage display app
countenance
发表于 2025-3-27 16:04:29
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不能妥协
发表于 2025-3-27 19:26:56
Taking Your iPad to the Max, iOS 5 Editionro and in vivo. Conjugation of other functional domains such as transcriptional regulatory domains and endonucleases to ZFPs provided powerful molecular tools to modulate endogenous gene expression and genetic information. These ZFP variants have been introduced into cells as DNA-encoding ZFP varian
Antagonism
发表于 2025-3-27 23:04:28
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组成
发表于 2025-3-28 03:13:40
Preparing Your Media in iTunes,rotein (ZFP). Depending on the effector domain, ATFs can up- or downregulate gene expression and thus represent powerful tools in biomedical research and allow novel approaches in clinical practice. Here, we describe the construction of ATFs directed against the promoter of the epithelial cell adhes
expound
发表于 2025-3-28 06:15:08
Touching Your Photos and Videosfinger zinc finger proteins (ZFPs) with distinct DNA-binding specificities, each of which is fused to a transcriptional activation or repression domain. Individual zinc fingers (ZFs) recognize their target DNA subsites and retain their binding specificities in the context of artificially constructed
Congeal
发表于 2025-3-28 13:13:41
Touching Your Photos and Videos,ns of this concept include cancer treatment, treatment of viral infections and, in general, treatment of any disease that could be attenuated by the stable repression of known target genes. We review the literature on targeted DNA methylation and gene silencing, summarize the achievements and the ch