PANEL
发表于 2025-3-26 23:24:48
Current Research Method in Transporter Study,situ/ex vivo, and in vivo methods have been established for studying transporter function and drug-transporter interaction. In this chapter, the major types of in vitro models for drug transport studies comprise membrane-based assays, cell-based assays (such as primary cell cultures, immortalized ce
言行自由
发表于 2025-3-27 02:59:52
Transporter-Mediated Drug-Drug Interactions and Their Significance,n of drugs. Drug transporters are generally divided into solute carrier (SLC) family and ATP binding cassette (ABC) family. Widely studied ABC family transporters include P-glycoprotein (P-GP), breast cancer resistance protein (BCRP), and multidrug resistance proteins (MRPs). SLC family transporters
陈腐思想
发表于 2025-3-27 05:21:34
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考得
发表于 2025-3-27 13:23:32
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SIT
发表于 2025-3-27 16:53:36
Intestinal Transporter-Associated Drug Absorption and Toxicity,nt role in the rate and extent of drug absorption of some, but not all, drug molecules. Due to the heterogeneous expression of multiple transporters along the intestine, the preferential absorption sites for drugs may vary significantly. In this chapter, we aim to summarize the current research on t
hair-bulb
发表于 2025-3-27 20:40:41
Contributions of Drug Transporters to Blood-Brain Barriers,forming the blood-cerebrospinal fluid barrier (BCSFB). Their main functions are to impede free diffusion between brain fluids and blood; to provide transport processes for essential nutrients, ions, and metabolic waste products; and to regulate the homeostasis of central nervous system (CNS), all of
先行
发表于 2025-3-28 01:51:40
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VERT
发表于 2025-3-28 03:32:11
Contributions of Drug Transporters to Blood-Placental Barrier,ental barrier are to regulate material transfer between the maternal and fetal circulation. The main functional units are the chorionic villi within which fetal blood is separated by only three or four cell layers (placental membrane) from maternal blood in the surrounding intervillous space. A seri
协迫
发表于 2025-3-28 10:12:48
ABC Transporter-Mediated Multidrug-Resistant Cancer,d by these proteins modulates the pharmacokinetics of many drugs and xenobiotics. These transporters are involved in the pathogenesis of several human diseases. The overexpression of certain transporters by cancer cells has been identified as a key factor in the development of resistance to chemothe
通情达理
发表于 2025-3-28 12:41:12
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