Banquet
发表于 2025-3-25 04:15:00
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使无效
发表于 2025-3-25 08:46:17
l for day-to-day interpretation of ADME studies.Multi discip.This book is intended for a broad readership, in particular, those working or interested in drug discovery coming from various disciplines such as medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinic
Aids209
发表于 2025-3-25 13:48:36
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本土
发表于 2025-3-25 18:57:05
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JOT
发表于 2025-3-25 23:19:12
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抛媚眼
发表于 2025-3-26 01:47:04
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BADGE
发表于 2025-3-26 05:36:03
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barium-study
发表于 2025-3-26 11:43:00
Goals for DMPK During Drug Optimizations,f a molecule’s interaction/modulation of a therapeutic target. What allows conversion of a potent chemical starting point to a final drug/drug candidate during the optimization process is the incorporation of appropriate ADME properties that balance efficacy and toxicity. Here we capture the high-le
财主
发表于 2025-3-26 14:29:56
Drug Properties, (1) an inability to demonstrate that the target can modulate the disease in a preclinical model, (2) the lack of a therapeutic index to modulate the target safely or (3) the inability to find molecules with the right balance of properties such as potency, selectivity, ADME properties, safety endpoi
ALTER
发表于 2025-3-26 17:42:35
DMPK Lead Optimization, optimization of molecules based on key ADME attributes. This has had a huge impact on the molecular design cycles: design, synthesis, assessment and re-design..In this chapter, we discuss the strategies for optimization of small molecules during drug discovery and address various ADME liabilities t