繁荣中国
发表于 2025-3-25 03:47:59
Performance and Characterization of Amorphous Solid Dispersions: An Overviewng drug absorption and the use of dimensionless numbers and absorption modeling in formulation selection. We provide an in-depth description of the concepts of supersaturation, crystallization, and speciation during dissolution, and their effect on product performance. Finally, solid-state failure m
ARM
发表于 2025-3-25 11:24:44
Practical Considerations for Spray Dried Formulation and Process Developments can also be used to obtain a fundamental understanding of the system and be predictive of changes across process spaces. The properties of spray dried powder are amenable to multiple drug delivery routes such as oral suspensions and solid oral dosage forms. However, the process and environmental s
Antagonism
发表于 2025-3-25 15:15:32
Leveraging Solid State Form and Physiochemical Properties for Early Clinical Formulation Efforts: Opubility in the excipient matrix, capsule cross-linking, as well as physical and chemical instability. Initially, telcagepant was formulated as a liquid LBF using the crystalline neutral form of the molecule, aided by in situ salt formation, and filled into hard-shell gelatin capsules. Following an e
FECK
发表于 2025-3-25 19:00:11
Book 2015d discovery and early development candidates, highlighting the link between solid state propertiesand critical development parameters such as solubility and stability. Final chapters center on techniques to improve molecular solubilization and prevent precipitation, with particularly emphasis on lin
nurture
发表于 2025-3-25 23:51:45
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脆弱吧
发表于 2025-3-26 03:35:19
,Die „Samstags gehört Vati mir“-Kampagne,o-end” formulation approaches for poorly soluble compounds, i.e., nanosizing or nanonization. The approach is broadly applicable for parenteral and non-parenteral dosage forms and has been commercially validated with the launch of products such as Rapamune., Emend., TriCor. 145, Triglide., Megace ES., Invega. Sustenna., Abraxane., and Juvedical..
溺爱
发表于 2025-3-26 06:09:55
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Osteoarthritis
发表于 2025-3-26 11:24:20
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Obsequious
发表于 2025-3-26 14:02:44
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善变
发表于 2025-3-26 20:50:20
https://doi.org/10.1007/978-3-322-87001-8mical properties of molecules through medicinal chemistry. Insights will be provided into the differences in approaches needed for optimization of a biological probe for target validation versus that of a hit to lead campaign, the design of more drug-like libraries, and the over-reliance of potency in optimization campaigns.