亚当心理阴影 发表于 2025-3-28 15:36:38
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Cannabinoids and Endocannabinoids in Metabolic Disorders with Focus on Diabetes,chidonoylglycerol, are deeply involved in all aspects of the control of energy balance in mammals. While initially it was believed that this endocannabinoid signaling system would only facilitate energy intake, we now know that perhaps even more important functions of endocannabinoids and CB. receptdiathermy 发表于 2025-3-29 02:15:20
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Inhibition of Ganglioside Biosynthesis as a Novel Therapeutic Approach in Insulin Resistance,” has arisen. By examining this working hypothesis, we demonstrate the molecular pathogenesis of type 2 diabetes and insulin resistance focusing on the interaction between insulin receptor and gangliosides in microdomains and propose the new therapeutic strategy “membrane microdomain ortho-signaling不给啤 发表于 2025-3-29 18:34:40
Overcoming Insulin Resistance with Ciliary Neurotrophic Factor,wide. Current interventions seem ineffective to halt this progression. With the failure of leptin as an anti-obesity therapeutic, ciliary neurotrophic factor (CNTF) has proven efficacious in models of obesity and leptin resistance, where leptin proved ineffective. CNTF is a gp130 ligand that has bee弄皱 发表于 2025-3-29 21:48:51
Thermogenesis and Related Metabolic Targets in Anti-Diabetic Therapy,mber or function of muscle mitochondria and the capacity for aerobic metabolism, all of which are low in many insulin-resistant subjects. Cannabinoid 1-receptor antagonists and β-adrenoceptor agonists improve insulin sensitivity in humans and promote fat oxidation in rodents independently of reducedENDOW 发表于 2025-3-29 23:58:48
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Fructose-1, 6-Bisphosphatase Inhibitors for Reducing Excessive Endogenous Glucose Production in Typbetes due to the well-recognized role of excessive endogenous glucose production (EGP) in the hyperglycemia characteristic of the disease. Inhibitors of FBPase are expected to fulfill an unmet medical need because the majority of current antidiabetic medications act primarily on insulin resistance o