Diverticulitis
发表于 2025-3-23 11:28:14
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敲竹杠
发表于 2025-3-23 14:23:34
Introduction,Protein-protein interactions (PPIs) play important roles in cell life activities, such as signal transduction, cell cycle, immune system, gene regulation, and so on.
CLEAR
发表于 2025-3-23 20:21:32
In-Tether Chiral Center Induced Helical Peptide Modulators Target p53-MDM2/MDMX and Inhibit Tumor GCancer is one of the most formidable diseases to combat. The cancer stem cell (CSC) hypothesis provides a compelling cellular mechanism to account for the therapeutic refractoriness and dormancy in cancer development.
NAV
发表于 2025-3-24 00:53:04
https://doi.org/10.1007/978-981-33-6613-8Stabilized peptide; Staple peptide; Chirality; Cell permeability; Helicity; Protein-protein interactions;
大漩涡
发表于 2025-3-24 05:01:11
978-981-33-6615-2Springer Nature Singapore Pte Ltd. 2021
reject
发表于 2025-3-24 08:47:44
Development of In-Tether Carbon Chiral Center-Induced Helical Peptide978-981-33-6613-8Series ISSN 2190-5053 Series E-ISSN 2190-5061
蒙太奇
发表于 2025-3-24 13:17:15
Book 2021ions (PPIs). The author designs and presents a novel helical peptide stabilization methodology by constructing a chiral cross-linker moiety, namely “chiral center induced peptide helicity (CIH)”. The book demonstrates that a precisely positioned carbon chiral center on tether can decisively determin
CLOUT
发表于 2025-3-24 16:32:26
Synthesis of In-Tether Chiral Center Peptides and Their Biophysical Properties Study,mportant. Many strategies have been developed and successfully applied. Early approaches to stabilize an α-helix involved both polar and physiological labile linkages, such as disulfide bonds and lactam bridges. A significant advance in this field was made by applying ring-closing metathesis to construct constrained peptides.
chalice
发表于 2025-3-24 20:20:10
Summary and Conclusion,et one after another and several of them have become blockbuster drugs for disease treatment. However, it should not be ignored that most of these peptide molecules are obtained from natural products or modified products of natural molecules. There are very few examples of artificially designed peptide molecules becoming drugs.
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发表于 2025-3-24 23:42:40
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