青春期
发表于 2025-3-23 13:08:54
https://doi.org/10.1007/978-3-658-07968-0contrast to conventional screening approaches, this process could identify hit compounds from unavailable mirror-image chiral natural products, thus providing unprecedented lead compounds for drug discovery.
远地点
发表于 2025-3-23 17:51:05
Introduction,meric form in nature, mirror-image isomers of them are also potential resources for drug discovery because they have identical physicochemical properties and different biological properties. To screen the mirror-image library of chiral natural products, mirror-image screening strategy has been devel
gangrene
发表于 2025-3-23 20:26:07
Development of a Mirror-Image Screening System for Chiral Natural Products, MDM2 and MDMX proteins has been established. MDM2 and MDMX are oncoproteins that negatively regulate the activity and stability of the tumor suppressor protein p53. The inhibitors of PPIs of MDM2-p53 and MDMX-p53 represent potential anticancer agents. Affinity-based chemical array screening is one
EWER
发表于 2025-3-23 23:25:56
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Ventricle
发表于 2025-3-24 02:42:34
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MODE
发表于 2025-3-24 08:19:53
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expository
发表于 2025-3-24 13:09:30
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协定
发表于 2025-3-24 18:50:34
Development of a Mirror-Image Screening System for Chiral Natural Products,fied from an in-house compound library by chemical array screening. The subsequent fluorescence polarization (FP) assay identified peptidic compounds that inhibited MDM2-p53 and MDMX-p53 interactions.
任命
发表于 2025-3-24 22:38:23
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飞来飞去真休
发表于 2025-3-25 03:14:15
Book 2018-image isomers of natural products are promising candidates for novel medicinal resources. . In an effort to identify anticancer agents from the mirror-image library, chemical protein syntheses of some target oncoproteins, MDM2, MDMX and Grb2, and their applications to the chemical array screening p