calcification
发表于 2025-3-21 19:29:32
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火光在摇曳
发表于 2025-3-22 00:17:03
Role of Nonhomologous End-Joining and Recombinational DNA Repair in Resistance to Nitrogen Mustard sported by carrier-mediated systems into cells and alkylate DNA, RNA, and proteins .. Alkylation of DNA and, more specifically, the formation of DNA interstrand crosslinks have been considered to be responsible for their cytotoxicity .. Resistance to the nitrogen mustards in murine and human tumor c
Palliation
发表于 2025-3-22 00:48:26
Repair of DNA Interstrand Crosslinks Produced by Cancer Chemotherapeutic Drugs,uch as the nitrogen mustards .. DNA was later identified as a target for these drugs ., and the covalent modification of DNA almost certainly accounts for the antitumor activity of these drugs (1). The fact that a bifunctional covalent reaction with DNA (crosslinking) is essential for the toxicity o
灵敏
发表于 2025-3-22 08:18:59
Chemosensitization to Platinum-Based Anticancer Drugs,ad, neck, and lung. Cisplatin shows considerable efficacy in the treatment of testicular cancers with cure rates of greater than 90% .. Despite its remarkable success in the treatment of cancer, its efficacy is limited by acquired or intrinsic resistance, and the mechanisms underlying chemoresistanc
举止粗野的人
发表于 2025-3-22 12:20:12
Regulation of DNA Repair and Apoptosis by p53 and Its Impact on Alkylating Drug Resistance of Tumoregregation. This protective mechanism is essential for maintaining genomic integrity and stability, cell viability, and prevention of mutations. The drugs used in the treatment of human malignancies are invariably genotoxic, and their effectiveness is limited by a variety of factors. The most import
机械
发表于 2025-3-22 14:22:43
Stress-Activated Signal Transduction Pathways in DNA Damage Response, cells develop an impressive arsenal of constitutive and/or inducible DNA-damage response mechanisms, which can deregulate the cell cycle checkpoints and DNA repair and allow cells to escape from apoptotic cell death.
机械
发表于 2025-3-22 20:40:47
Overcoming Resistance to Alkylating Agents by Inhibitors of ,,-Alkylguanine-DNA Alkyltransferase,or these agents and the correct repair of DNA damage provides protection from them .. Virtually every DNA repair pathway is able to interact with one or more facets of alkylation damage. Alkylated bases are repaired via base excision repair (BER), nucleotide excision repair (NER), and direct reversa
Calibrate
发表于 2025-3-23 00:14:40
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ADJ
发表于 2025-3-23 02:18:24
Potential Role of PARP Inhibitors in Cancer Treatment and Cell Death,c integrity (reviewed in refs. . and .). DNA damage induces a 10- to 500-fold increase in PARP-1 activity, which causes a drastic lowering of the cellular NAD. content. PARP-1 binds to DNA strand breaks and hydrolyzes NAD. to synthesize poly(ADP-ribose) chains (pADPr) on nuclear protein substrates,
Ballerina
发表于 2025-3-23 08:21:55
Relationship Among DNA Repair Genes, Cellular Radiosensitivity, and the Response of Tumors and Normlinically determined tolerance of the normal tissues in the radiation field .. The optimization of XRT treatment plans involves the computation of two factors for a given dose prescription: the tumor control probability (TCP) and the normal tissue complication probability (NTCP). The therapeutic out