Electrolysis 发表于 2025-3-30 09:15:59
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Quantification of DNA Modifications Using Two-Dimensional Ultraperformance Liquid Chromatography Tanbolic processes. 8-oxoguanine, one of the oxidatively modified DNA bases is a typical biomarker of oxidative stress. A noncanonical base, uracil, may also be present in small quantities in DNA. Ten-eleven translocation (TET) proteins are involved in oxidation of 5-methylcytosine to 5-hydroxymethylcy特征 发表于 2025-3-31 07:13:53
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Preparation of Internal Standards for 2D-UPLC-MS/MS Quantification of Noncanonical DNA Basesnternal standards. Only some of them are commercially available. Here we present a method allowing for the synthesis of [.C.,.N.]-5-methyl-2′-deoxycytidine from [.C.,.N.]-2′-deoxythymidine. We also describe an approach for the oxidation of [.C.,.N.]-5-methyl-2′-deoxycytidine and [.C.,.N.]-2′-deoxyth