轻打
发表于 2025-3-28 17:31:22
Cyclin-Dependent Kinase 5 (Cdk5): Linking Synaptic Plasticity and Neurodegeneration,ward an important role of Cdk5 in regulating synaptic plasticity, learning, and memory in the adult brain. However, aberrant Cdk5 activity has been implicated in various neurodegenerative diseases such as Alzheimer’s disease. Deregulation of Cdk5 has been attributed to calpain-mediated cleavage of t
门窗的侧柱
发表于 2025-3-28 21:44:11
,Cdk5 as a Drug Target for Alzheimer’s Disease,se. Since NFTs consist mainly of hyperphosphorylated tau, tau kinases have been suggested as drug targets to slow the progression of AD. This notion has further been supported by recent studies showing the importance of tau and its phosphorylation in neurodegeneration and cognitive deficits in anima
圆锥
发表于 2025-3-29 00:42:28
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colony
发表于 2025-3-29 06:19:09
Peter F. Pelz,Thomas Keil,Gerhard Ludwigspecific cdk5 inhibitor CP-681301 reduces ErbB2 receptor tyrosine phosphorylation. These results imply that cdk5 is involved in neuregulin-dependent activation of the PI3 K/Akt neuronal survival pathway and potentially other NRG-1-related signaling pathways by regulating the phosphorylation of ErbB2/ErbB3.
形容词
发表于 2025-3-29 08:10:59
Sub-Region Mixed Element II—V-Notch Problem35 to p25 by calpain, leading to hyperactivation and eventually neuronal cell death. The kinase activity and stability of Cdk5–p39, which still remains to be characterized, are also described here. The biochemical information will be useful in studying Cdk5 and elucidating its functions.
教义
发表于 2025-3-29 15:08:46
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intertwine
发表于 2025-3-29 17:03:28
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大猩猩
发表于 2025-3-29 22:46:23
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征税
发表于 2025-3-29 23:55:02
Cdk5 and Neuregulin-1 Signaling,specific cdk5 inhibitor CP-681301 reduces ErbB2 receptor tyrosine phosphorylation. These results imply that cdk5 is involved in neuregulin-dependent activation of the PI3 K/Akt neuronal survival pathway and potentially other NRG-1-related signaling pathways by regulating the phosphorylation of ErbB2/ErbB3.
Painstaking
发表于 2025-3-30 06:19:22
The Kinase Activity of Cdk5 and Its Regulation,35 to p25 by calpain, leading to hyperactivation and eventually neuronal cell death. The kinase activity and stability of Cdk5–p39, which still remains to be characterized, are also described here. The biochemical information will be useful in studying Cdk5 and elucidating its functions.