anthesis
发表于 2025-3-25 07:12:09
Cyclin-Dependent Kinase Inhibitors and Human Cancer,ves cells through mitosis and DNA replication. Elimination of CDK inhibitor activity, by mutation for instance, should release CDKs from this form of regulation and remove one of the restraints on cell growth.
Ingenuity
发表于 2025-3-25 09:21:02
Small-Molecule Inhibitors of Cyclin-Dependent Kinases: Molecular Tools and Potential Therapeutics,61, binding of a cyclin) and inhibitory ones (phosphorylation of T14, Y15, binding of a protein inhibitor, and ubiquitin-mediated proteolysis of the cyclin subunit). All represent potential points of intervention for the design of small-molecule inhibitors. Thus, in theory, it will be possible to id
制造
发表于 2025-3-25 12:12:39
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Melanocytes
发表于 2025-3-25 17:32:54
Book 1998 shown to be structurally conserved between yeast and man, but mammalian Cdks could substitute functionally for the endogenous enzymes in a yeast cell. The problem of cell cycle control was thought to have been virtually solved. The ensuing years have provided a much more complex view of cell cycle
杀虫剂
发表于 2025-3-25 21:27:42
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适宜
发表于 2025-3-26 02:59:38
Kazuo Matsuda,Yasuki Kansha,Akira Kishimotoaints, the highest likelihood is that such a small molecule will bind most tightly in small, defined pockets in the target protein, such as the ATP-binding pocket. The potential for disruption of a large protein—protein interface, such as a cyclin—CDK-binding surface, is much lower. It is therefore
成份
发表于 2025-3-26 07:02:58
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椭圆
发表于 2025-3-26 09:41:13
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Hdl348
发表于 2025-3-26 15:46:52
https://doi.org/10.1007/978-3-319-11547-4zed to date, fundamental mysteries remain concerning their biological roles and their regulation. The family, consisting so far of three members, is characterized by a C-terminal Cdk-inhibitory domain with a shared core homology and unrelated C-terminal domains of varying size (. et al. 1995; . et a
ETCH
发表于 2025-3-26 18:07:27
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