ostensible 发表于 2025-3-23 13:45:26
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History of the Personal Involvement Taboos role as a highly specialized and heterogeneous organ (N. 1959; M. et al. 1979; . L. and K. 1984; G. et al. 1978; J. and K. 1982), and an accurate physiological description of hepatic drug conjugation and conjugate processing by the liver necessitates consideration of the structure of the liver and航海太平洋 发表于 2025-3-24 09:48:27
Disciplined Personal Involvementhe basolateral domain between the plasma and the hepatocyte and across the canalicular domain between the hepatocyte and the bile canaliculus. Since most drug conjugates are anions, i.e., sulfate, glucuronide, or glutathione conjugates, this review will focus on the transport properties of organic aChronic 发表于 2025-3-24 12:00:12
Treating the Chronically Depressed Patientserve to convert drug metabolites either to compounds that are biologically active per se or to prodrugs that serve as carriers of biological activity to various tissues. This chapter reviews important examples of the role of phase II reactions in generating biologically active compounds. Among thetackle 发表于 2025-3-24 15:35:45
Treating the Chronically Depressed Patientently undergo phase II conjugation with glucuronic acid. Often such a conjugate constitutes the major metabolite. Many examples are found among the hypolipidemic agents, diuretic agents, and nonsteroidal anti-inflammatory drugs. Most herbicides are metabolized in this manner by fish, birds and mammacontrast-medium 发表于 2025-3-24 21:58:54
Health Anxiety and Somatization in Childrens of carcinogenesis. Glucuronides may be transport forms of carcinogens that play a major role in determining the target of carcinogenicity, for example, in urinary bladder or colon epithelium. Roles of UGT isozymes can be best appreciated in the context of overall xenobiotic metabolism. In addition溺爱 发表于 2025-3-25 02:46:34
Treatment: What Are the Choices?the sulfo group ( -SO.H , -SO.; B. and H. 1970) from the cofactor 3’-phospho-adenosine-5’-phosphosulfate (PAPS; R. and L. 1957) to the oxygen and nitrogen atoms of -C-OH, -N-OH, and -NH groups in physiological and foreign substrates (M. and J. 1990). The products of these transfers are sulfuric acid